Should new-onset arthralgia be considered a menopausal symptom?

600 Estrogen alone and joint symptoms in the Women’s Health Initiative randomized trial Rowan T. Chlebowski, MD, PhD, Dominic J. Cirillo, MD, PhD, Charles B. Eaton, MD, Marcia L. Stefanick, PhD, Mary Pettinger, MS, Laura D. Carbone, MD, MS, Karen C. Johnson, MD, MPH, Michael S. Simon, MD, MPH, Nancy F. Woods, PhD, RN, FAAN, and Jean Wactawski-Wende, PhD In this study the influence of estrogen alone use in joint symptoms in post-hoc analyses in the Women’s Health Initiative randomized, placebo-controlled clinical trial was examined. Estrogen alone use results in a modest but sustained reduction in joint pain.